Antibodies that detect ACAP2 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation and Immunohistochemistry (Paraffin). These antibodies target ACAP2 in Human, Mouse, Rat, Non-human primate and Equine samples. Our ACAP2 polyclonal antibodies are developed in Rabbit and Goat. Find the ACAP2 antibody that fits your needs. Choose from 1 of 10 ACAP2 antibodies, which have been validated in experiments with 1 publication and 21 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications. View more
ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
Arf GAP with coiled coil, ANK repeat and PH domains 2; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; centaurin beta2; centaurin, beta 2; Centaurin-beta-2; Cnt-b2