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ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.
ACCN; ACCN1; ACIC2; acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid sensing ion channel subunit 2; acid-sensing (proton-gated) ion channel 2; acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel neuronal 1; Asic2; ASIC2a; Bnac1; BNaC1a; BNC1; BNC1k; Brain sodium channel 1; degenerin; hBNaC1; Mammalian degenerin homolog; MDEG; MDEG1; MDEG2; neuronal amiloride-sensitive cation channel 1
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