Antibodies that detect CD180 (RP105) can be used in several scientific applications, including Flow Cytometry, Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin) and Functional assay. These antibodies target CD180 (RP105) in Human and Mouse samples. Our CD180 (RP105) monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse and Rat. Find the CD180 (RP105) antibody that fits your needs. Choose from 1 of 17 CD180 (RP105) antibodies, which have been validated in experiments with 7 publications and 27 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications. View more
CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. CD180 cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. CD180 consists of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is part of the cell surface receptor complex, RP105/MD-1. Diseases associated with CD180 dysfunction include Kawasaki Disease in children and may play a role in rheumatic disease pathology.
CD180; CD180 antigen; Ly-78; Lymphocyte antigen 78; MGC126233; MGC126234; Radioprotective 105 kDa protein