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DAZAP2 encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma.
AI314727; Brbp; DAZ associated protein 2; DAZAP2; DAZ-associated protein 2; deleted in azoospermia associated protein 2; deleted in azoospermia-associated protein 2; Gcap28; granule cell antiserum positive 28; gt6-12; KIAA0058; mKIAA0058; proline rich protein expressed in brain; proline-rich protein expressed in brain; proline-rich transcript in brain; proline-rich transcript, brain-expressed protein; PRTB
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