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This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation end products (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
advanced glycation endproduct receptor 1; advanced glycation end-product receptor 1; AGER1; AGE-R1; CDG1R; Ddost; DDOST 48 kDa subunit; dolichyl-diphosphooligosaccharide protein glycosyltransferase; dolichyl-diphosphooligosaccharide-protein glycosyltransferase; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic); dolichyl-di-phosphooligosaccharide-protein glycotransferase; dolichyl-diphosphooligosaccharide-protein glycotransferase; KIAA0115; MGC2191; OK/SW-cl.45; OKSWcl45; oligosaccharyl transferase 48 kDa subunit; oligosaccharyltransferase 48 kDa subunit; oligosaccharyltransferase OST48; oligosaccharyltransferase subunit 48; OST; OST48; WBP1; wu:fa11d01; zgc:66068; zgc:66068 protein; zgc:77478
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