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This gene encodes a GTPase-activating protein that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.
A730069N07Rik; ARHGAP 7; ARHGAP7; deleted in liver cancer 1; deleted in liver cancer 1 protein; Deleted in liver cancer 1 protein homolog; deleted in liver cancer 1 variant 2; deleted in liver cancer variant 4; DLC 1; DLC1; Dlc-1; DLC1 Rho GTPase activating protein; DLC1 Rho GTPase activating protein; rho GTPase-activating protein 7; FLJ21120; HP; HP protein; KIAA1723; p122 RhoGAP; p122-RhoGAP; rho GTPase activating protein 7; rho GTPase-activating protein 7; RhoGAP; Rho-GTPase-activating protein 7; rho-type GTPase-activating protein 7; STARD 12; STARD12; StAR-related lipid; StAR-related lipid transfer (START) domain containing 12; stAR-related lipid transfer protein 12; START domain-containing protein 12; transfer protein 12; unm_sa1141
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