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The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome.
1200017A24Rik; 5830472H07Rik; A130095G14Rik; AI461977; dedicator of cytokinesis 8; dedicator of cytokinesis protein 8; Dock8; epididymis luminal protein 205; HEL-205; MRD2; ZIR8
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