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Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I.
AW107337; G6Pase; G-6-Pase; G6Pase-alpha; G6PC; G6PC1; G6PT; Glc-6-Pase; Glc-6-Pase-alpha; glucose-6-phosphatase; Glucose-6-phosphatase alpha; glucose-6-phosphatase catalytic subunit; glucose-6-phosphatase, catalytic; glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease); glucose-6-phosphatase, catalytic subunit; GSD1; GSD1a; MGC163350; Unknown (protein for MGC:137220)
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