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GMNN inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
AW546347; Gem; geminin; Geminin GMNN; geminin, DNA replication inhibitor; GMNN; MGORS6; OTTHUMP00000039393; RP3 369A17.3
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