HIC1 Antibodies

Antibodies that detect HIC1 can be used in several scientific applications, including ELISA, Western Blot, Immunocytochemistry and Immunohistochemistry. These antibodies target HIC1 in Human, Mouse and Rat samples. Our HIC1 monoclonal and polyclonal antibodies are developed in Mouse,... Antibodies that detect HIC1 can be used in several scientific applications, including ELISA, Western Blot, Immunocytochemistry and Immunohistochemistry. These antibodies target HIC1 in Human, Mouse and Rat samples. Our HIC1 monoclonal and polyclonal antibodies are developed in Mouse, Rabbit and Goat. Find the HIC1 antibody that fits... Antibodies that detect HIC1 can be used in several scientific applications, including ELISA, Western Blot, Immunocytochemistry and Immunohistochemistry. These antibodies target HIC1 in Human, Mouse and Rat samples. Our HIC1 monoclonal and polyclonal antibodies are developed in Mouse, Rabbit and Goat. Find the HIC1 antibody that fits your needs. Choose from 1 of 14 HIC1 antibodies, which have been validated in experiments with 2 publications and 25 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re... Antibodies that detect HIC1 can be used in several scientific applications, including ELISA, Western Blot, Immunocytochemistry and Immunohistochemistry. These antibodies target HIC1 in Human, Mouse and Rat samples. Our HIC1 monoclonal and polyclonal antibodies are developed in Mouse, Rabbit and Goat. Find the HIC1 antibody that fits your needs. Choose from 1 of 14 HIC1 antibodies, which have been validated in experiments with 2 publications and 25 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.

同义词

AA408311; HIC1; hic-1; hypermethylated in cancer 1; hypermethylated in cancer 1 protein; ZBTB29; Zinc finger and BTB domain-containing protein 29; ZNF901

HIC1 Antibodies

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