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The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.
B930086D20Rik; DKFZp781N0678; HAMAP-Rule:MF_03156}; IMP (inosine 5'-monophosphate) dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; IMP dehydrogenase 1; IMP dehydrogenase 1 {ECO:0000255; IMPD; IMPD 1; IMPD 1 {ECO:0000255; IMPD1; IMPDH 1; IMPDH 1 {ECO:0000255; Impdh1; IMPDH-I; inosine 5'-phosphate dehydrogenase 1; inosine monophosphate dehydrogenase 1; inosine-5'-monophosphate dehydrogenase 1; inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255; LCA11; RP10; sWSS2608
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