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JHDM1D histone demethylase that specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. This specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. This demethylates H3K9me2 in absence of H3K4me3.
A630082K20Rik; BB041802; ENSMUSG00000073143; histone lysine demethylase JHDM1D; Jhdm1d; JmjC domain-containing histone demethylation protein 1D; jumonji C domain containing histone demethylase 1; jumonji C domain containing histone demethylase 1 homolog D; jumonji C domain-containing histone demethylase 1 homolog D; Kdm7; Kdm7a; Kiaa1718; lysine (K)-specific demethylase 7A; lysine demethylase 7A; lysine-specific demethylase 7; Lysine-specific demethylase 7A; mKIAA1718
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