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This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
1110004B06Rik; 4930526G11Rik; 9430067E15Rik; LOR2; Loxl2; Lysyl oxidase homolog 2; lysyl oxidase homolog 2; LOW QUALITY PROTEIN: lysyl oxidase homolog 2; lysyl oxidase like 2; lysyl oxidase related 2; lysyl oxidase-like 2; lysyl oxidase-like 2 delta e13; lysyl oxidase-like 2 protein; lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; lysyl oxidase-related protein WS9-14; WS9-14
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