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Myeloid tumor related gene (MTGR1) is found deleted in acute myeloid leukemia. Overexpression of MTGR1 can stimulate AML1-MTG8 to induce GCSF- dependent proliferation of L-G cells and to interfere with AML1- dependent transcription. AML1/MTG8 functions as a complex with MTGR1 and that the complex might be important in promoting leukemogenesis.
A430091M07; C330013D05Rik; CBFA2/RUNX1 partner transcriptional co-repressor 2; CBFA2/RUNX1 translocation partner 2; CBFA2T2; CBFA2T2 identified gene homolog; Cbfa2t2h; core-binding factor runt domain alpha subunit 2 translocated to 2 homolog; core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human); core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog; core-binding factor, runt domain, alpha subunit 2; translocated to, 2; DKFZp313F2116; EHT; ETO homolog on chromosome 20; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; MTGR1; myeloid translocation gene-related protein 1; myeloid translocation-related protein 1; p85; Protein CBFA2T2; RP5-1137F22.1; translocated to, 2; ZMYND3; ZMYND3 CBFA2T2
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