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NDE1 is s a member of the nuclear distribution E (NudE) family of proteins. It is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. NDE1 protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations to the gene lead to Lissencephaly 4 (LIS4) and Microhydranencephaly (MHAC).
2810027M15Rik; AU042936; AW822251; HOM-TES-87; LIS1-interacting protein NUDE1; LIS1-interacting protein NUDE1, rat homolog; LIS4; MHAC; mNudE; NDE; NDE1; nuclear distribution gene E homolog 1; nuclear distribution gene E homolog 1 (A nidulans); nuclear distribution protein nudE homolog 1; NudE; nudE neurodevelopment protein 1; nudE nuclear distribution E homolog 1; nudE nuclear distribution gene E homolog 1; Nude1; rNudE
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