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NEK2 is involved in cell cycle regulation and is essential for faithful chromosome segregation. NEK2 is a gene that encodes for a serine/threonine-protein kinase. This protein plays a crucial role in the regulation of mitosis and is primarily located in the centrosome. During the G1 phase, the protein is undetectable, but its levels progressively increase throughout the S phase, reaching their peak in late G2 phase. The gene has several alternatively spliced transcript variants that encode different isoforms with distinct C-termini. NEK2 is associated with several diseases, including Retinitis Pigmentosa 67 and Retinitis Pigmentosa.
AA617254; C77054; HSPK 21; HsPK21; NEK 2; NEK 2A; Nek2; Nek2 kinase; NEK2A; Never in mitosis A-related kinase 2; NIMA - related expressed kinase 2; NIMA (never in mitosis gene a)-related expressed kinase 2; NIMA (never in mitosis gene a)-related kinase 2; NIMA related kinase 2; nimA-like protein kinase 1; NIMA-related expressed kinase 2; NIMA-related kinase 2; nimA-related protein kinase 2; NLK 1; NLK1; PPP1R111; protein phosphatase 1, regulatory subunit 111; RP67; Serine/threonine-protein kinase Nek2
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