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Neurog 3 protein contains one basic helix-loop-helix (bHLH) domain.It is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors. Not only does itinitiates endocrine cell differentiation, italso promotes islet cell maturation and maintains islet function. It is reported that Neurogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather than goblet cell fate.
ATH4B; Atoh5; atonal homolog 5; BHLHA7; Class A basic helix-loop-helix protein 7; helix-loop-helix protein mATH-4B; LOW QUALITY PROTEIN: neurogenin-3; Math4B; Neurog3; neurogenin 3; Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B); neurogenin3; neurogenin-3; ngn3; NGN-3; Protein atonal homolog 5; Relax; transcriptional regulator, Relax
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