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The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
2610020K06Rik; 2610209F07Rik; 36.5kDa; 36kDa; A1 36 kDa subunit; activator 1 36 kDa subunit; Activator 1 subunit 5; MGC1155; Recc5; replication factor C (activator 1) 5; replication factor C (activator 1) 5, 36.5kDa; replication factor C 36 kDa subunit; replication factor C 5; replication factor C subunit 5; replication factor c subunit 5-like protein; replication factor C subunit RFC5; replication factor C, 36 kDa; replication factor C, 36-kDa subunit; RF-C 36 kDa subunit; RFC, 36.5 kD subunit; RFC36; Rfc5; rfc5 protein; Unknown (protein for MGC:128229); zgc:110313
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