SMCR8 Antibodies

Antibodies that detect SMCR8 can be used in several scientific applications, including Immunocytochemistry, Immunohistochemistry, Western Blot and Immunoprecipitation. These antibodies target SMCR8 in Human, Rat and Mouse samples. Our SMCR8 polyclonal and recombinant... Antibodies that detect SMCR8 can be used in several scientific applications, including Immunocytochemistry, Immunohistochemistry, Western Blot and Immunoprecipitation. These antibodies target SMCR8 in Human, Rat and Mouse samples. Our SMCR8 polyclonal and recombinant monoclonal antibodies are developed in Rabbit. Find the... Antibodies that detect SMCR8 can be used in several scientific applications, including Immunocytochemistry, Immunohistochemistry, Western Blot and Immunoprecipitation. These antibodies target SMCR8 in Human, Rat and Mouse samples. Our SMCR8 polyclonal and recombinant monoclonal antibodies are developed in Rabbit. Find the SMCR8 antibody that fits your needs. Choose from 1 of 6 SMCR8 antibodies, which have been validated in experiments with 18 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot... Antibodies that detect SMCR8 can be used in several scientific applications, including Immunocytochemistry, Immunohistochemistry, Western Blot and Immunoprecipitation. These antibodies target SMCR8 in Human, Rat and Mouse samples. Our SMCR8 polyclonal and recombinant monoclonal antibodies are developed in Rabbit. Find the SMCR8 antibody that fits your needs. Choose from 1 of 6 SMCR8 antibodies, which have been validated in experiments with 18 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes.

同义词

2310076G09Rik; AI642055; D030073L15Rik; FLJ34716; Guanine nucleotide exchange protein SMCR8; RGD1564621; SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog; Smith-Magenis syndrome chromosome region, candidate 8; Smith-Magenis syndrome chromosome region, candidate 8 homolog; Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)

SMCR8 Antibodies

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