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SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
5730552M22Rik; ESTM45; ESTM47; KIAA0488; MAP-responsive gene protein; methamphetamine (MAP) responsive transcript 1; methamphetamine-responsive transcript 1; methamphetamine-responsive transcript 1 protein; Mrt1; MY014; PDZ protein Mrt1; PDZ-protein Mrt1; R75405; RP11-98D18.12-005; SNX27; sorting nexin family member 27; sorting nexin-27
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