TRPC5 Antibodies

Target Information

TRPC5 belongs to the transient receptor family. TRPC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. The TRPC5 protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). TRPC5 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective, and may also be activated by intracellular calcium store depletion. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.

Synonyms

capacitative calcium entry channel 2; CCE2; hTRP5; Htrp-5; mtrp5; PPP1R159; protein phosphatase 1, regulatory subunit 159; short transient receptor potential channel 5; short transient receptor potential channel 5a; transient receptor potential cation channel, subfamily C, member 5a; transient receptor potential cation channel subfamily C member 5; transient receptor potential cation channel subfamily c member 5a; transient receptor potential cation channel, subfamily C, member 5; transient receptor potential cation channel, subfamily C, member 5a; transient receptor potential channel 5; transient receptor protein 5; TRP5; TRP-5; TrpC5; trpc5a; trp-related protein 5; Trrp5; vtransient receptor potential cation channel, subfamily C, member 5; wu:fi73f08