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USP9X is an ubiquitin-specific protease involved in the removal and recycling of ubiquitin from proteins degraded in proteasomes. As a deubiquitinating enzyme, USP9x has a critical function in tight junction biogenesis by controlling the levels of the exchange factor for Arf6 (EFA6), a protein shown to facilitate tight junction formation during a narrow temporal window preceding the establishment of cell polarity. USP9X is also located on the X-chromosome but escapes X-inactivation, and defects in USP9X may cause gonadal degeneration in Turner syndrome.
5730589N07Rik; AA407302; AA407699; AL022658; AL022749; Deubiquitinating enzyme FAF-X; DFFRX; Drosophila fat facets related, X-linked; FAF; Fafl; FAF-X; FAM; fat facets homolog; Fat facets in mammals; fat facets protein related, X-linked; fat facets protein-related, X-linked; fats facets protein related, X; hFAM; MRX99; MRXS99F; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; putative ubiquitin carboxyl-terminal hydrolase FAF-X; putative ubiquitin carboxyl-terminal hydrolase FAF-x-like protein; RGD1560056; Ubiquitin carboxyl-terminal hydrolase FAM; ubiquitin specific peptidase 9 X-linked; ubiquitin specific peptidase 9, X chromosome; ubiquitin specific peptidase 9, X-linked; ubiquitin specific protease 9 SSSRF- isoform; ubiquitin specific protease 9, X chromosome; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); ubiquitin specific protease 9, X-linked; ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X; USP9; USP9X
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