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This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
2010002J11Rik; Ac2-059; Pha2b; Prkwnk4; protein kinase lysine-deficient 4; Protein kinase with no lysine 4; protein kinase, lysine deficient 4; protein kinase, lysine-deficient 4; RP23-281C18.8; serine/threonine-protein kinase WNK4; WNK lysine deficient protein kinase 4; WNK4; WNK4 Ser/Thr kinase
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100 µg
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100 µL