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CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), FITC, eBioscience™

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产品信息

11-0519-42

应用
建议稀释比
已发表文章

免疫细胞化学 (ICC/IF)

-
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流式细胞分析 (Flow)

5 µL (1 µg)/test
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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1, kappa

推荐的同型对照

Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™

分类

Monoclonal

类型

Antibody

克隆号

23C6

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱 spectra

形式

Liquid

浓度

5 µL/Test

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with BSA

内含物

0.09% sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1907402

产品详细信息

Description: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. Heterodimers of CD51/CD61 are expressed by melanoma cells, endothelial cells and osteoclasts and at very low levels by platelets. The CD51/CD61 complex mediates adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin.

Applications Reported: The 23C6 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The 23C6 antibody has been pre-titrated and tested by flow cytometric analysis of human melanoma cell line and peripheral blood cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. This complex binds vitronection at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

生物信息学

蛋白别名: antigen CD61; antigen identified by monoclonal antibody L230; CD51; CD61; glycoprotein IIIa precursor; GPIIIa; integrin alpha-5 beta-3; Integrin alpha-V; integrin alphaVbeta3; integrin beta 3; integrin beta chain, beta 3; Integrin beta-3; integrin beta-3 subunit; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); plate glycoprotein IIIa (GPIIIa); Platelet membrane glycoprotein IIIa; unnamed protein product; vitronectin alpha subunit precursor; Vitronectin receptor; Vitronectin receptor subunit alpha

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基因别名: BDPLT16; BDPLT2; BDPLT24; CD51; CD61; GP3A; GPIIIa; GT; GT2; ITGAV; ITGB3; MSK8; VNRA; VTNR

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UniProt ID: (Human) P06756, (Human) P05106

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Entrez Gene ID: (Human) 3685, (Human) 3690

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功能
virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding signaling receptor activity neuregulin binding metal ion binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding protein disulfide isomerase activity platelet-derived growth factor receptor binding enzyme binding identical protein binding vascular endothelial growth factor receptor 2 binding cell adhesion molecule binding fibrinogen binding
参与通路
angiogenesis positive regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion positive regulation of leukocyte migration cell-substrate junction assembly cell adhesion cell-matrix adhesion integrin-mediated signaling pathway embryo implantation blood coagulation regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration cell migration platelet activation positive regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway cell-substrate adhesion negative regulation of lipid transport regulation of protein localization regulation of actin cytoskeleton organization cell adhesion mediated by integrin positive regulation of cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading tube development wound healing, spreading of epidermal cells response to platelet-derived growth factor cellular response to platelet-derived growth factor stimulus apolipoprotein A-I-mediated signaling pathway wound healing apoptotic cell clearance regulation of bone resorption positive regulation of angiogenesis positive regulation of bone resorption viral entry into host cell platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation mesodermal cell differentiation positive regulation of smooth muscle cell proliferation negative regulation of lipoprotein metabolic process regulation of developmental process negative chemotaxis regulation of transport regulation of release of sequestered calcium ion into cytosol regulation of serotonin uptake angiogenesis involved in wound healing regulation of biological quality positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to mechanical stimulus cellular response to xenobiotic stimulus positive regulation of glomerular mesangial cell proliferation blood coagulation, fibrin clot formation maintenance of postsynaptic specialization structure regulation of postsynaptic neurotransmitter receptor internalization regulation of postsynaptic neurotransmitter receptor diffusion trapping positive regulation of substrate adhesion-dependent cell spreading positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of vascular endothelial growth factor signaling pathway regulation of trophoblast cell migration regulation of extracellular matrix organization cellular response to insulin-like growth factor stimulus negative regulation of endothelial cell apoptotic process positive regulation of T cell migration blood vessel development vasculogenesis formation of primary germ layer positive regulation of cytosolic calcium ion concentration tissue development endodermal cell differentiation positive regulation of cell adhesion regulation of phagocytosis positive regulation of small GTPase mediated signal transduction ERK1 and ERK2 cascade calcium ion transmembrane transport transforming growth factor beta production entry into host cell by a symbiont-containing vacuole extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion positive regulation of intracellular signal transduction negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway
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