Product References
Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
JCI insight
Ruan W,Li J,Choi S,Ma X,Liang Y,Nair R,Yuan X,Mills TW,Eltzschig HK
14-5381-82 was used in Flow cytometry/Cell sorting to reveal a previously unrecognized role for myocyte-specific ENT1 in cardioprotection by enhancing myeloid-dependent Adora2b signaling during reperfusion.
Thu Jun 08 00:00:00 EDT 2023
Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection.
Theranostics
Chen Y,Zhang T,Yao F,Gao X,Li D,Fu S,Mao L,Liu F,Zhang X,Xu Y,Deng J,Li W,Fan G,Xiao C,Chen Y,Wang L,Guo W,Zhou B
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunohistochemistry
Thu Mar 10 00:00:00 EST 2022
Vascularized lymph node transplantation successfully reverses lymphedema and maintains immunity in a rat lymphedema model.
Bioengineering & translational medicine
Sakarya AH,Huang CW,Yang CY,Hsiao HY,Chang FC,Huang JJ
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunohistochemistry
Thu Sep 01 00:00:00 EDT 2022
CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells.
Science advances
Werder RB,Liu T,Abo KM,Lindstrom-Vautrin J,Villacorta-Martin C,Huang J,Hinds A,Boyer N,Bullitt E,Liesa M,Silverman EK,Kotton DN,Cho MH,Zhou X,Wilson AA
14-5381-82 was used in Immunohistochemistry-immunofluorescence to apply CRISPR interference to interrogate the function of nine genes implicated in COPD by GWAS in induced pluripotent stem cell-derived type 2 alveolar epithelial cells.
Fri Jul 15 00:00:00 EDT 2022
Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors.
Immunity
Lenti E,Genovese L,Bianchessi S,Maurizio A,Sain SB,di Lillo A,Mattavelli G,Harel I,Bernassola F,Hehlgans T,Pfeffer K,Crosti M,Abrignani S,Evans SM,Sitia G,Guimarães-Camboa N,Russo V,van de Pavert SA,Garcia-Manteiga JM,Brendolan A
14-5381-82 was used in Immunohistochemistry-immunofluorescence to identify the earliest embryonic sources of LN stromal and endothelial cells and demonstrates that stromal diversity begins already during LN development.
Tue Apr 12 00:00:00 EDT 2022
Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity.
Nature immunology
Prados A,Onder L,Cheng HW,Mörbe U,Lütge M,Gil-Cruz C,Perez-Shibayama C,Koliaraki V,Ludewig B,Kollias G
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Fibroblastic reticular cell response to dendritic cells requires coordinated activity of podoplanin, CD44 and CD9.
Journal of cell science
de Winde CM,Makris S,Millward LJ,Cantoral-Rebordinos JA,Benjamin AC,Martínez VG,Acton SE
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Thu Jul 15 00:00:00 EDT 2021
CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.
Theranostics
Tang C,Wang L,Sheng Y,Zheng Z,Xie Z,Wu F,You T,Ren L,Xia L,Ruan C,Zhu L
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Mon Feb 07 00:00:00 EST 2022
CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.
Theranostics
Tang C,Wang L,Sheng Y,Zheng Z,Xie Z,Wu F,You T,Ren L,Xia L,Ruan C,Zhu L
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Mon Feb 07 00:00:00 EST 2022
CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.
Theranostics
Tang C,Wang L,Sheng Y,Zheng Z,Xie Z,Wu F,You T,Ren L,Xia L,Ruan C,Zhu L
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Mon Feb 07 00:00:00 EST 2022
Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes.
PLoS biology
Fujimoto N,He Y,D'Addio M,Tacconi C,Detmar M,Dieterich LC
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth.
eLife
Thacker VV,Dhar N,Sharma K,Barrile R,Karalis K,McKinney JD
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunocytochemistry
Tue Nov 24 00:00:00 EST 2020
Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges.
Acta neuropathologica
Shibata-Germanos S,Goodman JR,Grieg A,Trivedi CA,Benson BC,Foti SC,Faro A,Castellan RFP,Correra RM,Barber M,Ruhrberg C,Weller RO,Lashley T,Iliff JJ,Hawkins TA,Rihel J
14-5381-82 was used in Immunohistochemistry to identify a structurally and functionally similar cell type in the mammalian leptomeninges that we name Leptomeningeal Lymphatic Endothelial Cells.
Sat Feb 01 00:00:00 EST 2020
IL-4 promotes stromal cell expansion and is critical for development of a type-2, but not a type 1 immune response.
European journal of immunology
Cortes-Selva D,Ready A,Gibbs L,Rajwa B,Fairfax KC
14-5381-82 was used in Flow Cytometry to reveal a role of IL-4 in the maintenance of peripheral lymphoid organ microenvironments during homeostasis and antigenic challenge.
Fri Mar 01 00:00:00 EST 2019
Single cell RNA sequencing identifies TGFβ as a key regenerative cue following LPS-induced lung injury.
JCI insight
Riemondy KA,Jansing NL,Jiang P,Redente EF,Gillen AE,Fu R,Miller AJ,Spence JR,Gerber AN,Hesselberth JR,Zemans RL
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunofluorescence
Tue Mar 26 00:00:00 EDT 2019
Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability.
International journal of cancer
Dieterich LC,Kapaklikaya K,Cetintas T,Proulx ST,Commerford CD,Ikenberg K,Bachmann SB,Scholl J,Detmar M
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Fri Nov 15 00:00:00 EST 2019
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
The Journal of experimental medicine
Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B
14-5381 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.
Mon Apr 02 00:00:00 EDT 2018
Podoplanin is an important stromal prognostic marker in perihilar cholangiocarcinoma.
Oncology letters
Obulkasim H,Shi X,Wang J,Li J,Dai B,Wu P,Wang S,Wang X,Ding Y
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Endogenous Galectin-9 Suppresses Apoptosis in Human Rheumatoid Arthritis Synovial Fibroblasts.
Scientific reports
Pearson MJ,Bik MA,Ospelt C,Naylor AJ,Wehmeyer C,Jones SW,Buckley CD,Gay S,Filer A,Lord JM
14-5381-82 was used in Immunohistochemistry to determine the role of endogenous Galectins in the inflammatory pathology of the rheumatoid arthritis synovium in humans.
Mon Aug 27 00:00:00 EDT 2018
Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis.
Blood
Payne H,Ponomaryov T,Watson SP,Brill A
14-5381 was used in Western Blotting to identify a novel mechanism of deep vein thrombosis, whereby CLEC-2 and podoplanin upregulation in the venous wall trigger thrombus formation.
Thu Apr 06 00:00:00 EDT 2017
Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis.
Blood
Payne H,Ponomaryov T,Watson SP,Brill A
14-5381 was used in Western Blotting to identify a novel mechanism of deep vein thrombosis, whereby CLEC-2 and podoplanin upregulation in the venous wall trigger thrombus formation.
Thu Apr 06 00:00:00 EDT 2017
Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.
American journal of physiology. Lung cellular and molecular physiology
Lax S,Rayes J,Wichaiyo S,Haining EJ,Lowe K,Grygielska B,Laloo R,Flodby P,Borok Z,Crandall ED,Thickett DR,Watson SP
14-5381 was used in Immunohistochemistry to study the mechanism by which platelets regulate pathogenic processes that occur during acute respiratory distress syndrome.
Fri Dec 01 00:00:00 EST 2017
Cornea lymphatics drive the CD8+ T-cell response to herpes simplex virus-1.
Immunology and cell biology
Gurung HR,Carr MM,Carr DJ
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
Stem cell function and stress response are controlled by protein synthesis.
Nature
Blanco S,Bandiera R,Popis M,Hussain S,Lombard P,Aleksic J,Sajini A,Tanna H,Cortés-Garrido R,Gkatza N,Dietmann S,Frye M
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunofluorescence
Thu Jun 16 00:00:00 EDT 2016
Stem cell function and stress response are controlled by protein synthesis.
Nature
Blanco S,Bandiera R,Popis M,Hussain S,Lombard P,Aleksic J,Sajini A,Tanna H,Cortés-Garrido R,Gkatza N,Dietmann S,Frye M
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunofluorescence
Thu Jun 16 00:00:00 EDT 2016
Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers.
Journal of hepatology
Lua I,Li Y,Zagory JA,Wang KS,French SW,Sévigny J,Asahina K
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunohistochemistry
Sun May 01 00:00:00 EDT 2016
Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers.
Journal of hepatology
Lua I,Li Y,Zagory JA,Wang KS,French SW,Sévigny J,Asahina K
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunohistochemistry
Sun May 01 00:00:00 EDT 2016
GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease.
The Journal of experimental medicine
Stock AT,Hansen JA,Sleeman MA,McKenzie BS,Wicks IP
14-5381 was used in Immunofluorescence in immunohistochemistry on frozen tissues to determine the role of granulocyte/macrophage colony stimulating factor in cardiac inflammation in Kawasaki disease.
Mon Sep 19 00:00:00 EDT 2016
Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification.
Annals of surgery
Loder S,Agarwal S,Sorkin M,Breuler C,Li J,Peterson J,Gardenier J,Hsieh HH,Wang SC,Mehrara BJ,Levi B
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2016
Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Shinoda K,Hirahara K,Iinuma T,Ichikawa T,Suzuki AS,Sugaya K,Tumes DJ,Yamamoto H,Hara T,Tani-Ichi S,Ikuta K,Okamoto Y,Nakayama T
14-5381 was used in Flow cytometry/Cell sorting to investigate how pathogenic Th cells are maintained at sites of local inflammation, showing that Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche.
Tue May 17 00:00:00 EDT 2016
PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection.
PLoS pathogens
Nobs SP,Schneider C,Heer AK,Huotari J,Helenius A,Kopf M
14-5381 was used in Flow cytometry/Cell sorting to identify PI3Kγ as a novel key host protective factor in influenza virus infection.
Tue Mar 01 00:00:00 EST 2016
Structural and functional features of central nervous system lymphatic vessels.
Nature
Louveau A,Smirnov I,Keyes TJ,Eccles JD,Rouhani SJ,Peske JD,Derecki NC,Castle D,Mandell JW,Lee KS,Harris TH,Kipnis J
14-5381 was used in Immunohistochemistry-wholemount to investigate the mechanisms governing the entrance and exit of immune cells from the CNS.
Thu Jul 16 00:00:00 EDT 2015
Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development.
Blood
Lowe KL,Finney BA,Deppermann C,Hägerling R,Gazit SL,Frampton J,Buckley C,Camerer E,Nieswandt B,Kiefer F,Watson SP
14-5381 was used in Immunofluorescence to investigate the mechanisms behind a platelet-specific deletion of the C-type-lectin-like receptor (CLEC-2) causing hemorrhaging in the brain at mid-gestation in mice.
Thu Jun 11 00:00:00 EDT 2015
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.
The Journal of clinical investigation
Hitchcock JR,Cook CN,Bobat S,Ross EA,Flores-Langarica A,Lowe KL,Khan M,Dominguez-Medina CC,Lax S,Carvalho-Gaspar M,Hubscher S,Rainger GE,Cobbold M,Buckley CD,Mitchell TJ,Mitchell A,Jones ND,Van Rooijen N,Kirchhofer D,Henderson IR,Adams DH,Watson SP,Cunningham AF
14-5381 was used in Immunohistochemistry to indicate that infection-driven thrombosis follows local inflammation, upregulation of podoplanin and platelet activation.
Tue Dec 01 00:00:00 EST 2015
Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction.
PLoS pathogens
Lynskey NN,Banerji S,Johnson LA,Holder KA,Reglinski M,Wing PA,Rigby D,Jackson DG,Sriskandan S
14-5381 was used in Immunofluorescence to provide evidence to implicate the hyaluronan capsule as a critical bacterial determinant of group A streptococcus lymphoid tropism.
Tue Sep 01 00:00:00 EDT 2015
Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L.
Transplantation
Nakayama Y,Brinkman CC,Bromberg JS
14-5381 was used in Flow cytometry/Cell sorting to elucidate the mechanisms facilitating bidirectional communication between fibroblastic reticular cells and CD4(+) T cells.
Sat Aug 01 00:00:00 EDT 2015
Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer.
PloS one
Kitamura J,Uemura M,Kurozumi M,Sonobe M,Manabe T,Hiai H,Date H,Kinoshita K
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunohistochemistry
Mon Mar 30 00:00:00 EDT 2015
Diverse profiles of ricin-cell interactions in the lung following intranasal exposure to ricin.
Toxins
Sapoznikov A,Falach R,Mazor O,Alcalay R,Gal Y,Seliger N,Sabo T,Kronman C
14-5381 was used in Immunohistochemistry to examine the interactions between ricin and cells of the lungs following intranasal exposure.
Tue Nov 17 00:00:00 EST 2015
Alveolar progenitor and stem cells in lung development, renewal and cancer.
Nature
Desai TJ,Brownfield DG,Krasnow MA
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunofluorescence
Thu Mar 13 00:00:00 EDT 2014
Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
Nature
Acton SE,Farrugia AJ,Astarita JL,Mourão-Sá D,Jenkins RP,Nye E,Hooper S,van Blijswijk J,Rogers NC,Snelgrove KJ,Rosewell I,Moita LF,Stamp G,Turley SJ,Sahai E,Reis e Sousa C
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunohistochemistry
Thu Oct 23 00:00:00 EDT 2014
Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
Nature
Acton SE,Farrugia AJ,Astarita JL,Mourão-Sá D,Jenkins RP,Nye E,Hooper S,van Blijswijk J,Rogers NC,Snelgrove KJ,Rosewell I,Moita LF,Stamp G,Turley SJ,Sahai E,Reis e Sousa C
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunohistochemistry
Thu Oct 23 00:00:00 EDT 2014
Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
Nature
Acton SE,Farrugia AJ,Astarita JL,Mourão-Sá D,Jenkins RP,Nye E,Hooper S,van Blijswijk J,Rogers NC,Snelgrove KJ,Rosewell I,Moita LF,Stamp G,Turley SJ,Sahai E,Reis e Sousa C
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunohistochemistry
Thu Oct 23 00:00:00 EDT 2014
Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells.
The Journal of experimental medicine
Jarjour M,Jorquera A,Mondor I,Wienert S,Narang P,Coles MC,Klauschen F,Bajénoff M
14-5381 was used in Flow cytometry/Cell sorting to investigate the ontogeny and dynamics of lymph node follicular dendritic cells in situ.
Mon Jun 02 00:00:00 EDT 2014
Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury.
Hepatology (Baltimore, Md.)
Lua I,James D,Wang J,Wang KS,Asahina K
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunofluorescence
Tue Jul 01 00:00:00 EDT 2014
Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.
PLoS biology
Kizhatil K,Ryan M,Marchant JK,Henrich S,John SW
14-5381 was used in Immunofluorescence to study how SC development resembles a blend of vascular developmental programs.
Tue Jul 01 00:00:00 EDT 2014
C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo.
Clinical and experimental immunology
Ruseva MM,Takahashi M,Fujita T,Pickering MC
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunofluorescence
Tue Apr 01 00:00:00 EDT 2014
PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels.
PloS one
Zotes TM,Spada R,Mulens V,Pérez-Yagüe S,Sorzano CO,Okkenhaug K,Carrera AC,Barber DF
14-5381 was used in Flow cytometry/Cell sorting to study the expression and function of p110δ in the murine spleen and lymph node.
Wed Apr 16 00:00:00 EDT 2014
Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.
The Journal of biological chemistry
Iwasaki T,Takeda Y,Maruyama K,Yokosaki Y,Tsujino K,Tetsumoto S,Kuhara H,Nakanishi K,Otani Y,Jin Y,Kohmo S,Hirata H,Takahashi R,Suzuki M,Inoue K,Nagatomo I,Goya S,Kijima T,Kumagai T,Tachibana I,Kawase I,Kumanogoh A
14-5381 was used in Western Blotting to demonstrate that tetraspanin CD9 modulates molecular organization of integrins in lymphatic endothelial cells, thereby supporting several functions required for lymphangiogenesis.
Fri Jan 25 00:00:00 EST 2013
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-5381 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-5381 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Nakayama Y,Bromberg JS
14-5381 was used in Flow cytometry/Cell sorting to study the effect of LTβRIg treatment in a murine cardiac allograft model.
Sat Sep 01 00:00:00 EDT 2012
Responsive culture platform to examine the influence of microenvironmental geometry on cell function in 3D.
Integrative biology : quantitative biosciences from nano to macro
Kloxin AM,Lewis KJ,DeForest CA,Seedorf G,Tibbitt MW,Balasubramaniam V,Anseth KS
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunofluorescence
Sat Dec 01 00:00:00 EST 2012
Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development.
Hepatology (Baltimore, Md.)
Asahina K,Tsai SY,Li P,Ishii M,Maxson RE,Sucov HM,Tsukamoto H
Published figure using Podoplanin monoclonal antibody (Product # 14-5381-82) in Immunofluorescence
Sun Mar 01 00:00:00 EST 2009
