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Proteintech
CD21 Recombinant Mouse Monoclonal Antibody (BU32)
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图: 1 / 3
CD21 Antibody (65512-1-MR) in Flow
1x10^6 human PBMCs were surface stained with 0.1 µg Anti-Human CD21 Mouse Recombinant Antibody (65512-1-MR, Clone: BU32) (left) or 0.1 µg Anti-Human CD21 Mouse Monoclonal Antibody (Clone: BU32) (center and right) and CoraLite®647-Conjugated Donkey Anti-Mouse IgG (H+L) at dilution 1:1,000. Cells were then stained with CL488-Conjugated Anti-Human CD3. Cells were not fixed. Lymphocytes were gated.
产品信息
65512-1-MR
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
Expression System
proprietary
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BU32
抗原
complement component (3d/Epstein Barr virus) receptor 2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Wet ice
靶标信息
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD21; Complement C3d receptor; Complement C3d receptor (C3DR); complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; Complement receptor type 2; Complement Receptor type 2 (CR2); Cr2; CR2 precursor; CR2/CD21/C3d/Epstein-Barr virus receptor precursor; EBV receptor; EBV-R; Epstein-Barr virus receptor; EVBR; unnamed protein product
基因别名: C3DR; CD21; CR; CR2; CVID7; SLEB9
UniProt ID: (Human) P20023
Entrez Gene ID: (Human) 1380
immune system process
complement receptor mediated signaling pathway
T cell mediated immunity
immune response
complement activation, alternative pathway
complement activation, classical pathway
B cell differentiation
B cell proliferation
B cell activation
innate immune response
negative regulation of complement activation, classical pathway
viral entry into host cell
type I interferon signaling pathway
antiviral innate immune response
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