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Proteintech
USP5 Monoclonal Antibody (3F12C10)
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产品信息
66213-1-IG
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
3F12C10
抗原
USP5 Fusion Protein Ag7575 (1-350 aa encoded by BC005139)
偶联物
形式
Liquid
浓度
0.91 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAELSEEAL LSVLPTIRVP KAGDRVHKDE CAFSFDTPES EGGLYICMNT FLGFGKQYVE RHFNKTGQRV YLHLRRTRRP KEEDPATGTG DPPRKKPTRL AIGVEGGFDL SEEKFELDED VKIVILPDYL EIARDGLGGL PDIVRDRVTS AVEALLSADS ASRKQEVQAW DGEVRQVSKH AFSLKQLDNP ARIPPCGWKC SKCDMRENLW LNLTDGSILC GRRYFDGSGG NNHAVEHYRE TGYPLAVKLG TITPDGADVY SYDEDDMVLD PSLAEHLSHF GIDMLKMQKT DKTMTELEID MNQRIGEWEL IQESGVPLKP LFGPGYTGIR NLGNSCYLNS VVQVLFSIPD F (1-350 aa encoded by BC005139)
靶标信息
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in unanchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Deubiquitinating enzyme 5; Isopeptidase T; testicular tissue protein Li 218; ubiquitin carboxy terminal hydrolase T; Ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5; ubiquitin specific protease 5 (isopeptidase T); Ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); Ubiquitin-specific-processing protease 5
基因别名: AA407472; ISOT; ISOT-1; Ucht; USP5
UniProt ID: (Human) P45974, (Mouse) P56399
Entrez Gene ID: (Human) 8078, (Rat) 297593, (Mouse) 22225
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
zinc ion binding
ubiquitin binding
omega peptidase activity
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
metal ion binding
cysteine protease
ubiquitin-dependent protein catabolic process
protein deubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein K48-linked deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
proteolysis
