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Proteintech
C4 gamma chain Monoclonal Antibody (2G6A7)
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Product Details
66242-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2G6A7
Immunogen
C4 gamma chain Fusion Protein Ag10449 (1-202 aa encoded by BC012372)
Conjugate
Form
Liquid
Concentration
0.81 mg/mL
Amount
121.5 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody raised against 1543-1744aa of human C4-A protein recognizes C4 gamma chain.
Immunogen sequence: EVPVGLVQP ASATLYDYYN PERRCSVFYG APSKSRLLAT LCSAEVCQCA EGKCPRQRRA LERGLQDEDG YRMKFACYYP RVEYGFQVKV LREGSRAAFR LFETKITQVL HFTKDVKAAA NQMRNFLVRA SCRLRLEPGK EYLIMGLDGA TYDLEGHPQY LLESNSWIEE MPSERLCRST RQRAACAQLN DFLQEYGTQG CQV (1-202 aa encoded by BC012372)
Target Information
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acidic C4; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; c4 complement; c4 propeptide; C4A anaphylatoxin; Complement C4-A; complement C4A (Rodgers blood group); complement component 4A (Rodgers blood group); MHC class III region complement; Rodgers form of C4; unnamed protein product; ZA
Gene Aliases: C4; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD2; RG
UniProt ID: (Human) P0C0L4
Entrez Gene ID: (Human) 720
complement activation, lectin pathway
activation of membrane attack complex
immune system process
inflammatory response
complement activation
complement activation, classical pathway
opsonization
killing of cells of other organism
innate immune response
protein maturation
complement activation, GZMK pathway
positive regulation of apoptotic cell clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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