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CDK9 Monoclonal Antibody (1G6B3)
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FIGURE: 1 / 2
CDK9 Antibody (67256-1-IG) in ICC/IF
Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CDK9 antibody (67256-1-Ig, Clone: 1G6B3) at dilution of 1:1,000 and Multi-rAb CoraLite Plus 594-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM004, 1:500) were used for detection.
Product Details
67256-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G6B3
Immunogen
CDK9 fusion protein Ag29178
Conjugate
Form
Liquid
Concentration
1.7 mg/mL
Amount
255 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAKQYDSVEC PFCDEVSKYE KLAKIGQGTF GEVFKARHRK TGQKVALKKV LMENEKEGFP ITALREIKIL QLLKHENVVN LIEICRTKAS PYNRCKGSIY LVFDFCEHDL AGLLSNVLVK FTLSEIKRVM QMLLNGLYYI HRNKILHRDM KAANVLITRD GVLKLADFGL ARAFSLAKNS QPNRYTNRVV TLWYRPPELL LGERDYGPPI DLWGAGCIMA EMWTRSPIMQ GNTEQHQLAL ISQLCGSITP EVWPNVDNYE LYEKLELVKG QKRKVKDRLK AYVRDPYALD LIDKLLVLDP AQRIDSDDAL NHDFFWSDPM PSDLKGMLST HLTSMFEYLA PPRRKGSQIT QQSTNQSRNP ATTNQTEFER VF
Target Information
CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-2K; CDC2-related kinase; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; unnamed protein product
Gene Aliases: C-2k; CDC2L4; CDK9; CTK1; PITALRE; TAK
UniProt ID: (Human) P50750, (Mouse) Q99J95, (Rat) Q641Z4
Entrez Gene ID: (Human) 1025, (Mouse) 107951, (Rat) 362110
nucleotide binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription coactivator binding
DNA binding
chromatin binding
obsolete transcription elongation regulator activity
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
transferase activity
snRNA binding
protein kinase binding
7SK snRNA binding
protein serine kinase activity
transcription factor binding
transferase activity, transferring phosphorus-containing groups
transcription regulatory region DNA binding
non-receptor serine/threonine protein kinase
DNA repair
regulation of DNA repair
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein phosphorylation
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
cell proliferation
replication fork processing
regulation of mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
positive regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
regulation of muscle cell differentiation
nucleus localization
regulation of cell cycle
cellular response to cytokine stimulus
negative regulation of protein localization to chromatin
positive regulation of protein localization to chromatin
transcription elongation-coupled chromatin remodeling
transcription pausing by RNA polymerase II
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of cardiac muscle hypertrophy
phosphorylation
regulation of histone modification
positive regulation of histone phosphorylation
replication fork arrest
negative regulation of cell cycle arrest
negative regulation of mRNA polyadenylation
positive regulation of mRNA 3'-UTR binding
positive regulation of histone H2B ubiquitination
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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