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Antibodies Inc
Ataxin-1/WT Monoclonal Antibody (N65/37), FL594
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Product Details
75-102-FL594
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N65/37
Immunogen
Synthetic peptide amino acids 746-761 of mouse ataxin-1 (accession number P54254).
Conjugate
Excitation/Emission Max
594/615 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: RKRRRWSAPE TRKLEK
Target Information
Ataxin-1 (ATXN1) is a protein encoded by the ATXN1 gene. It is primarily known for its association with spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder. The "WT" designation refers to the wild-type, or normal, form of the protein as opposed to mutant forms associated with disease. Ataxin-1 plays a critical role in maintaining normal neuronal function, and its dysregulation due to genetic mutations leads to severe neurodegenerative conditions. Research into Ataxin-1 continues to be vital for developing therapeutic approaches for these disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alt-ATXN1; alternative ataxin1; Ataxin-1; spinocerebellar ataxia 1; spinocerebellar ataxia 1 homolog; Spinocerebellar ataxia type 1 protein; Spinocerebellar ataxia type 1 protein homolog
Gene Aliases: 2900016G23Rik; ATX1; ATXN1; C85907; D6S504E; ENSMUSG00000074917; Gm10786; SCA1
UniProt ID: (Human) P54253, (Mouse) P54254, (Rat) Q63540
Entrez Gene ID: (Human) 6310, (Mouse) 20238, (Rat) 25049
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
adult locomotory behavior
visual learning
negative regulation of phosphorylation
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
nuclear export
excitatory postsynaptic potential
positive regulation of glial cell proliferation
biological_process
transcription from RNA polymerase II promoter
RNA processing
brain development
learning
memory
social behavior
insulin-like growth factor receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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