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Kir6.2 Potassium Channel Monoclonal Antibody (N363/71), FL490
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Product Details
75-393-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N363/71
Immunogen
Fusion protein amino acids 345-390 of rat Kir6.2 (accession number P70673) produced recombinantly in E. Coli.
Conjugate
FL490
FL490
FL490
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: TARQLDEDRS LLDALTLASS RGPLRKRSVA VAKAKPKFSI SPDSLS
Target Information
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI842722; AW491124; BIR; inward rectifier K(+) channel Kir6.2; IRK11; KATP; KATP channel; Kir6; MGC133230; potassium channel, inwardly rectifying subfamily J member 11; potassium voltage-gated channel subfamily J member 11; unnamed protein product
Gene Aliases: Kir6.2; mBIR
UniProt ID: (Mouse) Q61743, (Rat) P70673
Entrez Gene ID: (Mouse) 16514, (Rat) 83535
inward rectifier potassium channel activity
voltage-gated potassium channel activity
protein binding
ATP binding
ATP-activated inward rectifier potassium channel activity
cation-transporting ATPase activity
ankyrin binding
potassium ion binding
heat shock protein binding
ion channel binding
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
action potential
response to hypoxia
response to ischemia
ventricular cardiac muscle tissue development
glucose metabolic process
potassium ion transport
apoptotic process
response to stress
determination of adult lifespan
response to xenobiotic stimulus
cellular response to nutrient levels
response to estradiol
response to ATP
response to testosterone
regulation of membrane potential
negative regulation of insulin secretion
regulation of insulin secretion
neurological system process
transmembrane transport
CAMKK-AMPK signaling cascade
cellular response to nicotine
cellular response to glucose stimulus
cellular response to tumor necrosis factor
potassium ion transmembrane transport
regulation of presynaptic membrane potential
positive regulation of protein localization to plasma membrane
response to resveratrol
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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