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Proteintech
EFHD2 Recombinant Rabbit Monoclonal Antibody (240185H5)
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Product Details
83264-5-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
240185H5
Immunogen
EFHD2 fusion protein Ag35084
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ATDELATKLS RRLQMEGEGG GETPEQPGLN GAAAAAAGAP DEAAEALGSA DCELSAKLLR RADLNQGIGE PQSPSRRVF
Target Information
EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLC-gamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EF hand domain containing 2; EF hand domain family, member D2; EF-hand domain family, member D2; EF-hand domain-containing protein D2; MGC4342; RP3-467K16.3; swiprosin 1; Swiprosin-1; testicular tissue protein Li 62
Gene Aliases: EFHD2; SWS1
UniProt ID: (Human) Q96C19
Entrez Gene ID: (Human) 79180
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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