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Invitrogen
ACACB Polyclonal Antibody
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ACACB Antibody (PA5-114376) in IHC (P)
Immunohistochemistry analysis of ACACB in paraffin-embedded rat testis tissue. Antigen retrieval was performed with citrate buffer (pH6, 20 min). Samples were blocked with 10% goat serum and incubated in ACACB polyclonal antibody (Product # PA5-114376) at a dilution of 1 µg/mL (overnight, 4°C), followed by biotinylated goat anti-rabbit IgG (30 min, 37°C) and Strepavidin-Biotin-Complex (SABC) with DAB.
产品信息
PA5-114376
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human Acetyl Coenzyme A Carboxylase/ACACB (EENPEVAVDCVIYLSQHISPAERAQVVHLLSTMD).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat skeletal muscle tissue, mouse skeletal muscle tissue. IHC: rat testis tissue. Flow: HL-60 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage. May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACC-beta; Acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase 2; acetyl-Coenzyme A carboxylase beta
基因别名: ACACB; ACC2; ACCB; AI597064; AW743042; HACC275
UniProt ID: (Human) O00763, (Mouse) E9Q4Z2
Entrez Gene ID: (Human) 32, (Rat) 116719, (Mouse) 100705
acetyl-CoA metabolic process
fatty acid biosynthetic process
positive regulation of lipid storage
response to organic cyclic compound
response to drug
negative regulation of fatty acid oxidation
protein homotetramerization
positive regulation of heart growth
malonyl-CoA biosynthetic process
lipid metabolic process
fatty acid metabolic process
metabolic process
biotin metabolic process
carnitine shuttle
negative regulation of gene expression
regulation of glucose metabolic process
positive regulation of cellular metabolic process
response to nutrient levels
negative regulation of fatty acid beta-oxidation
negative regulation of catalytic activity
energy homeostasis
