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Invitrogen
ADAMTS9 Polyclonal Antibody
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FIGURE: 1 / 3
ADAMTS9 Antibody (PA5149878) in IHC (P)
Immunohistochemistry analysis of ADAMTS9 in paraffin-embedded Human Small intestine tissue. Samples were incubated with ADAMTS9 Polyclonal (Product # PA5149878) antibody using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5149878
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 9 (ADAMTS9) (Cys1727-Leu1935)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The immunizing peptide sequence is 100% conserved between human, mouse and rat. ADAMTS9 is a member of the ADAMs family of proteinases with Thrombospondin motifs. ADAMTS9 is closest in homology to ADAMTS20, sharing 54% overall identity, and like ADAMTS20 ADAMTS9 gas a GON-like domain at the carboxyterminal end. The GON domain at the carboxyterminal end is similar to the GON-1 protein in C. elegans, mutations of which lead to defective gonadal development. ADAMTS9 is expressed in ovary and testis, but little is known about the role of ADAMTS9 in reproductive organs. ADAMTS9 is also expressed in the heart, placenta, lung, skeletal tissue, and pancreas, so the protein must have wider functions than just gonadal development. ADAMTS9, like ADAMTS20, has a total of 15 thrombospondin-like domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 9; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9; ADAM; ADAM-TS 9; ADAMs; ADAMTS9; ADAMTS9B; secreted zinc-binding metalloprotease; JSCFDG; metalloendopeptidases; unnamed protein product
Gene Aliases: ADAMTS9; KIAA1312
UniProt ID: (Human) Q9P2N4
Entrez Gene ID: (Human) 56999
lens development in camera-type eye
heart valve morphogenesis
ventricular cardiac muscle tissue development
proteolysis
response to bacterium
negative regulation of endothelial cell migration
protein transport
vesicle-mediated transport
extracellular matrix organization
melanocyte differentiation
aorta morphogenesis
positive regulation of melanocyte differentiation
regulation of developmental pigmentation
camera-type eye morphogenesis
cornea development in camera-type eye
endothelial cell-matrix adhesion
negative regulation of sprouting angiogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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