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Alomone Labs, LTD
AKAP12 Polyclonal Antibody
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AKAP12 Antibody (APZ-033-200UL) in IHC (F)
Expression of AKAP12 in rat cerebellum - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-AKAP12 Antibody (#APZ-033), (1:400), followed by goat Anti-rabbit-AlexaFluor-488. AKAP12 immunoreactivity (green) is detected in Purkinje cells and their dendritic trees (arrows). Cell nuclei are stained with DAPI (blue).
产品信息
APZ-033-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)GNLTKESPDTNGPK, corresponding to amino acid residues 1639-1652 of mouse AKAP12, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; A-kinase anchor protein 12; A-kinase anchor protein 250 kDa; A-kinase anchor protein, 250kDa; AKAP 250; AKAP-12; gercelin; Germ cell lineage protein gercelin; Gravin; kinase scaffold protein gravin; Myasthenia gravis autoantigen; myasthenia gravis autoantigen gravin; Src-Suppressed C Kinase Substrate; SSeCKS; SSeCKS, Gravin, AKAP250; testis specific gene A12; v-src suppressed transcript 5
基因别名: AI317366; AKAP12; AKAP12A; AKAP12B; AKAP12G; AKAP250; Gag12; Srcs5; SSeCKS; Tsga12
UniProt ID: (Human) Q02952, (Mouse) Q9WTQ5, (Rat) Q5QD51
Entrez Gene ID: (Human) 9590, (Mouse) 83397, (Rat) 83425
