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Invitrogen
ALKBH3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-76827
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human ALKBH3.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alkB homolog 3, alpha-ketoglutaratedependent dioxygenase; alkB, alkylation repair homolog 3; ALKBH3; AlkB; alkylated DNA repair protein alkB homolog 3; alkylation repair-like protein 3; DEPC 1; FLJ43614; m MGC118790; MGC118792; MGC118793; MGC134125; prostate cancer antigen-1; RP23-375N21.4
基因别名: 1700108H04Rik; 1810020C19Rik; ABH3; DEPC-1; DEPC1; hABH3; mABH3; PCA1
UniProt ID: (Human) Q96Q83, (Mouse) Q8K1E6, (Rat) Q5XIC8
Entrez Gene ID: (Human) 221120, (Mouse) 69113, (Rat) 362169
protein binding
ferrous iron binding
oxidative RNA demethylase activity
oxidative DNA demethylase activity
dioxygenase activity
RNA N1-methyladenosine dioxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
cytosine C-5 DNA demethylase activity
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