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Invitrogen
ALS2CR2 Polyclonal Antibody
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产品信息
PA1-4314
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide: S(399) P W S E L E F Q F P D D K D P V W E F(418)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-4314 detects the PAPK protein in mouse samples.
PA1-4314 has been successfully used in Western blot procedures.
The PA1-4314 immunizing peptide corresponds to amino acid residues 399-418 of the mouse PAPK protein.
靶标信息
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; ILP-interacting protein homolog; MGC102916; polyploidy associated protein kinase; Polyploidy-associated protein kinase; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STRAD beta
基因别名: AA792893; Als2cr2; B830008M19; D1Ucla2; ILPIP; ILPIPA; Papk; PRO1038; Stradb; Syradb
UniProt ID: (Mouse) Q8K4T3
Entrez Gene ID: (Mouse) 227154
cell morphogenesis
protein phosphorylation
protein export from nucleus
cytoskeleton organization
cell cycle
JNK cascade
Rho protein signal transduction
regulation of mitotic cell cycle
cell migration
actin cytoskeleton organization
activation of protein kinase activity
regulation of MAPK cascade
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
