Invitrogen

ALX3 Polyclonal Antibody

Name: ALX3 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-36138

查看其他4个ALX3抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

ALX3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ALX3 Antibody (PA5-36138) in IHC (P)

Immunohistochemistry analysis of ALX3 in paraffin-embedded human kidney carcinoma tissue (nucleus staining) and negative control (right, with PBS only). Samples were incubated with ALX3 polyclonal antibody (Product # PA5-36138) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.

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Immunogen image

Immunogen Image ALX3 Polyclonal Antibody

产品信息

PA5-36138

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 171-220 of human ALX3

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2553385

产品详细信息

This antibody detects endogenous protein at a molecular weight of 36 kDa.

Purity is >95% by SDS-PAGE.

靶标信息

Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predominant ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression. Alx3 (-) mice lack a phenotype distinct from wild-type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.

仅用于科研。不用于诊断过程。未经明确授权不得转售。