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AML-ETO Polyclonal Antibody
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FIGURE: 1 / 2
AML-ETO Antibody (600-401-X43) in WB
Western Blot analysis using Anti-AML-ETO. Figure A: Schematic representation of the construction of GST-fusion proteins containing different parts of AML-ETO were constructed and run on a 15% polyacrylamide gel. Figure B: Western Blot was performed on seven GST-fusion proteins containing different fragments of AML-ETO (1-7) with Anti-AML-ETO, diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. A molecular weight marker (in kDa) is shown on the left; the location of the protein of interest is indicated on the right. The antibody raised... View More
Product Details
600-401-X43
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-AML-ETO Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides from the human AML-ETO fusion protein. The antibody recognizes the ETO (RUNX1T1) part of the fusion protein.
Conjugate
Form
Liquid
Concentration
0.2 µg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.05% ProClin 300, 0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acute myelogenous leukemia 1 translocation 1 protein; acute myelogenous leukemia 1 translocation 1, cyclin-D related; CBFA2T1; CBFA2T1 identified gene homolog; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; Cyclin-D-related protein; Eight twenty one protein; ETO; fusion gene; MGC2796; MTG8b; myeloid translocation gene on 8q22; Protein CBFA2T1; Protein ETO; Protein MTG8; putative transcription factor; runt related transcription factor 1; translocated to, 1 (cyclin D related); runt-related transcription factor 1; translocated to, 1 (cyclin D-related); RUNX1 translocation partner 1; unnamed protein product; Zinc finger MYND domain-containing protein 2
Gene Aliases: AML1-MTG8; AML1T1; CBFA2T1; Cbfa2t1h; CDR; ETO; MTG8; RUNX1T1; ZMYND2
UniProt ID: (Human) Q06455, (Mouse) Q61909
Entrez Gene ID: (Human) 862, (Mouse) 12395
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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