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Invitrogen
APBA2 Polyclonal Antibody
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APBA2 Antibody (PA5-47830) in WB
Western blot analysis of APBA2 in human brain (cortex) tissue and human brain (hippocampus) tissue. Samples were incubated in APBA2 polyclonal antibody (Product # PA5-47830) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. A specific band was detected for APBA2 at approximately 120 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
PA5-47830
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human APBA2 Ala2-Leu165
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects human APBA2 in direct ELISAs and human, mouse and rat in Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) APBA1 and rhAPBA3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding family A member 2 (X11-like); amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); amyloid beta A4 precursor protein-binding family A member 2; Amyloid-beta A4 precursor protein-binding family A member 2; Mint 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11-like protein
基因别名: APBA2; D15S1518E; HsT16821; LIN-10; MGC:14091; MINT2; mXllL; X11-BETA; X11-like; X11L; XllL
UniProt ID: (Human) Q99767, (Rat) O35431, (Mouse) P98084
Entrez Gene ID: (Human) 321, (Rat) 83610, (Mouse) 11784
