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Invitrogen
APITD1 Polyclonal Antibody
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APITD1 Antibody (PA5-121184) in WB
Western blot analysis of APITD1 in extracts of various cell lines. Samples were incubated with APITD1 Polyclonal antibody (Product # PA5-121184) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-121184
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
形式
Liquid
浓度
2.17 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: U-251MG, SW620, NCI-H460, MCF7, A-549. The target is usually found in the following locations: Chromosome, Nucleus, centromere, kinetochore.
Immunogen sequence: MEEEAETEEQ QRFSYQQRLK AAVHYTVGCL CEEVALDKEM QFSKQTIAAI SELTFRQCEN FAKDLEMFAR HAKRTTINTE DVKLLARRSN SLLKYITDKS EEIAQINLER KAQKKKKSED GSKNSRQPAE AGVVESEN
靶标信息
APITD1 was identified in the neuroblastoma tumour suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumours, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apoptosis-inducing TAF9-like domain-containing protein 1; CENP-S; Centromere protein S; FANCM-associated histone fold protein 1; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa
基因别名: APITD1; CENP-S; CENPS; FAAP16; MHF1
UniProt ID: (Human) Q8N2Z9
Entrez Gene ID: (Human) 378708
resolution of meiotic recombination intermediates
DNA repair
mitotic recombination
cellular response to DNA damage stimulus
sister chromatid cohesion
mitotic nuclear division
replication fork processing
positive regulation of protein ubiquitination
CENP-A containing nucleosome assembly
interstrand cross-link repair
cell division
kinetochore assembly
