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Invitrogen
ASAP1 Polyclonal Antibody
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ASAP1 Antibody (PA5-23323) in WB
Western blot analysis of ASAP1 in mouse brain lysate in the 1) absence and 2) presence of immunizing peptide. Samples were incubated in ASAP1 polyclonal antibody (Product # PA5-23323) using a dilution of 2.0 µg/mL followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
产品信息
PA5-23323
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Within the range of amino acids 962-999 of mouse ASAP1.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Sequence homology: Chicken (85%).
靶标信息
ASAP1, also known as Development and differentiation enhancing factor 1, is a protein with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. ASAP1 is a homodimer known to interact with SRC and CRK and its activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2). It possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. It may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2 and may also function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. It is widely expressed in most of the tissues. ASAP1 is a protooncogene involved in invasive breast cancer and in other types of invasive and malignant tumors, such as uveal melanomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; DEF-1; development and differentiation enhancing factor 1; Development and differentiation-enhancing factor 1; differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP
基因别名: Asap1; AV239055; Ddef1; DEF-1; Kiaa1249; mKIAA1249; PAP; s19; Shag1
UniProt ID: (Mouse) Q9QWY8, (Rat) Q1AAU6
Entrez Gene ID: (Mouse) 13196, (Rat) 314961
