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Invitrogen
ASB2 Polyclonal Antibody
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ASB2 Antibody (PA5-120594) in WB
Western blot analysis of ASB2 in extracts of various cell lines. Samples were incubated with ASB2 Polyclonal antibody (Product # PA5-120594) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-120594
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment).
偶联物
形式
Liquid
浓度
1.71 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: 293T, rat spleen, rat kidney.
Immunogen sequence: MDLGCDGEPC FSCLYGNGPH PPAPQPSSRF NDAPAADKEP SVVQFCEFVS APEVSRWAGP IIDVLLDYVG NVQLCSRLKE HIDSFEDWAV IKEKAEPPRP LAHLCRLRVR KAIGKYRIKL LDTLPLPGRL IRYLKYENTQ
靶标信息
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ankyrin repeat and SOCS box protein 2; ankyrin repeat and SOCS box-containing protein 2; ankyrin repeat and SOCS box-containing protein 2a; ASB-2; asb2 {ECO:0000312|EMBL:AAH85882.1}; MGC40044
基因别名: ASB-2; ASB2
UniProt ID: (Human) Q96Q27, (Rat) Q5U2S6
Entrez Gene ID: (Human) 51676, (Rat) 299266
protein polyubiquitination
positive regulation of defense response to virus by host
signal transduction
intracellular signal transduction
skeletal muscle cell differentiation
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
myoblast differentiation
mitophagy in response to mitochondrial depolarization
xenophagy
