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Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; ankyrin-like 1; Ankyrin-like protein 1; ASZ1; Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein
基因别名: ALP1; ANKL1; ASZ1; C7orf7; CT1.19; GASZ; Orf3
UniProt ID: (Human) Q8WWH4
Entrez Gene ID: (Human) 136991, (Rat) 170578