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Invitrogen
ATP5A1 Monoclonal Antibody (7H10BD4F9)
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图: 1 / 28
ATP5A1 Antibody (459240) in ICC/IF
Bovine pulmonary artery endothelial cells: Mitochondria were labeled using an anti-OxPhos Complex V subunit a, mouse IgG2b monoclonal antibody (Product # 459240) prelabeled with the Zenon® Alexa Fluor® 555 Mouse IgG2b Labeling Kit (Product # Z-25205). Tubulin was detected with an anti-a-tubulin mouse IgG2b monoclonal antibody prelabeled with the Zenon® Alexa Fluor® 488 Mouse IgG2b Labeling Kit (Product # Z-25202), and The nucleus was stained with DAPI (Product # D1306, D3571, D21490).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
459240
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
已发表种属
Bovine,
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
7H10BD4F9
抗原
Bovine Complex V
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.0 mg/mL
规格
100 µg
纯化类型
IgG fraction
保存液
HEPES buffered saline
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Use Isolated mitochondria from Human, Rat, Bovine and Mouse Heart, and HepG2, Cultured Human embryonic lung-derived fibroblasts (strain MRC5), HL-60 cells for positive controls.
靶标信息
The ATP5F1A gene (ATP Synthase F1 Subunit Alpha) is located on chromosome 18q21.33 and encodes a critical component of the mitochondrial ATP synthase complex, specifically the F1 catalytic core. The ATP synthase complex is essential for cellular energy production, facilitating the conversion of ADP to ATP during oxidative phosphorylation. The ATP5F1A subunit is responsible for the catalysis of ATP synthesis driven by the proton gradient across the inner mitochondrial membrane. Dysfunctions or mutations in ATP5F1A can result in mitochondrial disorders and are linked to various metabolic and neurodegenerative diseases. Understanding the structure and function of ATP5F1A is vital for comprehending the bioenergetics of cellular respiration and has implications in studying mitochondrial pathologies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alpha subunit ATP synthase isoform precursor (EC 3.6.1.34); ATP synthase alpha subunit; ATP synthase alpha subunit precursor; ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase F1 subunit alpha; ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1; iso; mitochondrial H+-ATP synthase alpha subunit; modifier of Min 2
基因别名: AI035633; AL022851; AL023067; ATP5A; ATP5A1; ATP5A2; ATP5AL2; ATP5F1A; ATPM; D18Ertd206e; Mom2
UniProt ID: (Bovine) P19483, (Rat) P15999, (Mouse) Q03265
Entrez Gene ID: (Bovine) 282578, (Rat) 65262, (Mouse) 11946
protein binding
ATP binding
ATPase activity
MHC class I protein binding
ADP binding
poly(A) RNA binding
proton-transporting ATP synthase activity, rotational mechanism
proton-transporting ATPase activity, rotational mechanism
nucleotide binding
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
ATP synthase
negative regulation of endothelial cell proliferation
lipid metabolic process
ATP synthesis coupled proton transport
ATP hydrolysis coupled proton transport
ATP metabolic process
hydrogen ion transmembrane transport
ATP biosynthetic process
transport
ion transport
embryo development
proton transport
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