Invitrogen

Adiponectin Monoclonal Antibody (19F1)

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22个已发表图片
31 篇参考文献
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说明书
实验方案
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Adiponectin Monoclonal Antibody (19F1)

产品信息

MA1-054

应用
建议稀释比
已发表文章

免疫印迹 (WB)

2 µg/mL
查看15篇已发表文章 15篇已发表文章

免疫组化 (IHC)

-
查看4篇已发表文章 4篇已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent
查看1篇已发表文章 1篇已发表文章

免疫组织化学（多聚甲醛固定） (IHC (PFA))

-
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

2 µg/mL
查看3篇已发表文章 3篇已发表文章

酶联免疫吸附实验 (ELISA)

Assay-dependent
查看1篇已发表文章 1篇已发表文章

亲和纯化 (AP)

-
查看4篇已发表文章 4篇已发表文章

其他PubMed (Misc)

-
查看2篇已发表文章 2篇已发表文章
产品规格

种属反应

Human, Mouse, Rabbit

已发表种属

Bovine, C. elegans, Human, Mouse, Rabbit

宿主/亚型

Mouse / IgG

分类

Monoclonal

类型

Antibody

克隆号

19F1

抗原

Full length, recombinant, human adiponectin.
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_557516

产品详细信息

MA1-054 detects adiponectin from human, rabbit and mouse samples.

MA1-054 has been used successfully in Western blot, immunofluorescence, and ELISA procedures. By Western blot this antibody detects ~30 kDa protein representing Adiponectin in 3T3-L1 adipocytes. Immunofluorescence and ELISA of Adiponectin can also be performed using MA1-054.

The MA1-054 immunogen is full length, recombinant, human adiponectin.

靶标信息

Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 30 kDa adipocyte complement-related protein; ACRP30; adipocyte complement related protein; Adipocyte complement-related 30 kDa protein; adipocyte complement-related protein of 30 kDa; adipocyte, C1Q and collagen domain containing; Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ; Adiponectin; Adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; ADPIOQ; apM-1; Gelatin-binding protein; gelatin-binding protein 28

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基因别名: 30kDa; ACDC; ACRP30; Ad; adipo; ADIPOQ; ADIPQTL1; ADPN; APM-1; APM1; APN; GBP28

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UniProt ID: (Human) Q15848, (Mouse) Q60994

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Entrez Gene ID: (Human) 9370, (Rabbit) 100009027, (Mouse) 11450

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功能
receptor binding cytokine activity hormone activity protein binding sialic acid binding identical protein binding protein homodimerization activity
参与通路
response to hypoxia positive regulation of protein phosphorylation glucose metabolic process generation of precursor metabolites and energy fatty acid beta-oxidation response to nutrient circadian rhythm response to sucrose response to glucose positive regulation of signal transduction negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of protein kinase A signaling negative regulation of macrophage derived foam cell differentiation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of glucose metabolic process response to activity negative regulation of smooth muscle cell migration fatty acid oxidation negative regulation of cell migration negative regulation of granulocyte differentiation negative regulation of protein autophosphorylation positive regulation of cellular protein metabolic process negative regulation of tumor necrosis factor production positive regulation of interleukin-8 production cellular response to insulin stimulus positive regulation of myeloid cell apoptotic process adiponectin-activated signaling pathway negative regulation of heterotypic cell-cell adhesion low-density lipoprotein particle clearance response to tumor necrosis factor cellular response to drug glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity response to ethanol negative regulation of fat cell differentiation negative regulation of macrophage differentiation negative regulation of low-density lipoprotein particle receptor biosynthetic process negative regulation of gluconeogenesis negative regulation of blood pressure positive regulation of blood pressure negative regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of glucose import negative regulation of hormone secretion negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation negative regulation of phagocytosis negative regulation of synaptic transmission brown fat cell differentiation protein homooligomerization response to glucocorticoid membrane depolarization membrane hyperpolarization protein heterotrimerization negative regulation of ERK1 and ERK2 cascade response to linoleic acid detection of oxidative stress cellular response to cAMP positive regulation of monocyte chemotactic protein-1 production cellular response to epinephrine stimulus protein localization to plasma membrane negative regulation of intracellular protein transport negative regulation of receptor binding negative regulation of DNA biosynthetic process positive regulation of glycogen (starch) synthase activity positive regulation of metanephric glomerular visceral epithelial cell development positive regulation of cAMP-dependent protein kinase activity positive regulation of renal albumin absorption negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of metanephric mesenchymal cell migration positive regulation of protein kinase activity
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