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Invitrogen
AgRP Polyclonal Antibody
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FIGURE: 1 / 1
AgRP Antibody (PA5-142144) in IHC (PFA)
Immunohistochemistry (PFA) analysis of AgRP in PFA-perfused cryosection of Human Hypothalamus using AgRP Polyclonal Antibody (Product # PA5-142144) at 0.05 µg/mL. Antigen retrieval with citrate buffer pH 6 at 80C for 30 min, HRP-staining with Ni-DAB after Biotin-SP-antigoat amplification. Data obtained by Prof. Erik Hrabovszky, Inst, Exp, Med., Budapest, Hungary.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-142144
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence CRKLGTAMNPCSRT (aa 119-132).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognise both reported isoforms (as represented by NP_001129; NP_015531).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. In humans, the agouti-related peptide is encoded by the AGRP gene. This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: agouti related protein homolog
Gene Aliases: AGRT; ART; ASIP2
UniProt ID: (Human) O00253
Entrez Gene ID: (Human) 181
neuropeptide signaling pathway
circadian rhythm
adult feeding behavior
hormone-mediated signaling pathway
regulation of appetite
positive regulation of appetite
response to insulin
eating behavior
long-day photoperiodism
maternal process involved in female pregnancy
regulation of feeding behavior
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of feeding behavior
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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