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Invitrogen
Aggrecan Monoclonal Antibody (969D4D11)
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Aggrecan Antibody (AHP0022) in ICC/IF
Regenerative biomaterials 2020 -
Figure 1 Immunophenotypic and morphological features of MSCs and chondrocytes in direct co-culture. (A) Immunohistochemical staining of type I, II, X collagen and aggrecan in MSCs/chondrocytes after 17 days of differentiation in direct 2D and 3D co-culture model (EnVision technique, scale bar = 50 um); (B) Chondrocytes and (G) direct co-culture on culture flask (inverted phase contrast microscope, scale bar... View More
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.jpg?time=20240507?time=20240507 "Aggrecan Antibody (AHP0022) in IHC (P)")
.jpg?time=20240507?time=20240507 "Aggrecan Antibody (AHP0022) in IHC (P)")
产品信息
AHP0022
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Bovine,
C. elegans,
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
969D4D11
抗原
Human natural aggrecan (proteoglycan), purified from human articular cartilage.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.5mg/mL sodium azide
保存条件
4°C
运输条件
Wet ice
RRID
产品详细信息
This product is recommended as a detection antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 969D 4D11 2A9.
靶标信息
Aggrecan also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1 is a protein that is encoded by the ACAN gene. The encoded protein is an integral part of the extracellular matrix in cartilaginous tissue and it withstands compression in cartilage. The human form of the protein is 2316 amino acids long (approximately 250 kDa) and can be expressed in multiple isoforms due to alternative splicing. Aggrecan exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. The synthesis and degradation of aggrecan are being investigated for their roles in cartilage deterioration during joint injury, disease, and aging. It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a result of cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 can be used to detect these neo epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Aggrecan core protein; Cartilage-specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1; Chondroitin sulfate proteoglycan core protein 1; CSPCP; large aggregating proteoglycan
基因别名: ACAN; AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK
UniProt ID: (Human) Q9UCP4
Entrez Gene ID: (Human) 176
