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Invitrogen
Ankyrin B Monoclonal Antibody (2.2)
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图: 1 / 6
Ankyrin B Antibody (33-3700) in ICC/IF
Immunofluorescent analysis of Ankyrin B was done on 70% confluent log phase SHSY5Y cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with Ankyrin B Mouse monoclonal Antibody (Product # 33-3700) at 1 µg/mL in 1% BSA and incubated for 3 hours at room temperat... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
33-3700
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Fruit fly,
Hamster,
Human,
Insect,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2.2
抗原
Synthetic peptide derived from the human ankyrin B protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ANK-2; ank2; ankyrin 2, brain; ankyrin 3, epithelial; Ankyrin-2; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin
基因别名: AI835472; Ank-2; ANK2; Ank3; ANKB; AW491075
UniProt ID: (Mouse) Q8C8R3
Entrez Gene ID: (Mouse) 109676, (Rat) 362036
regulation of heart rate
cellular calcium ion homeostasis
signal transduction
protein localization
positive regulation of gene expression
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
regulation of protein stability
T-tubule organization
protein localization to cell surface
cellular protein localization
protein localization to M-band
protein localization to T-tubule
regulation of apoptotic process
positive regulation of potassium ion transport
protein stabilization
regulation of calcium ion transport
positive regulation of calcium ion transport
regulation of cardiac muscle contraction
cardiac muscle contraction
protein localization to endoplasmic reticulum
protein localization to plasma membrane
protein targeting to plasma membrane
regulation of cardiac muscle cell contraction
atrial cardiac muscle cell action potential
SA node cell action potential
regulation of cardiac muscle cell membrane potential
atrial cardiac muscle cell to AV node cell communication
SA node cell to atrial cardiac muscle cell communication
regulation of heart rate by cardiac conduction
regulation of AV node cell action potential
regulation of SA node cell action potential
regulation of atrial cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transporter activity
regulation of calcium ion transmembrane transporter activity
positive regulation of calcium ion transmembrane transporter activity
regulation of cation channel activity
positive regulation of cation channel activity
atrial septum development
nervous system development
paranodal junction assembly
protein localization to organelle
regulation of release of sequestered calcium ion into cytosol
response to methylmercury
regulation of ventricular cardiac muscle cell membrane repolarization
ventricular cardiac muscle cell action potential
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