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Invitrogen
BEND2 Polyclonal Antibody
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产品信息
PA5-31747
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human BEND2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: U87-MG.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The BEND2 gene, located on chromosome Xp22.2, encodes a protein that is part of the BEN domain-containing family, which is implicated in chromatin organization and transcriptional regulation. BEND2 is critical in spermatogenesis, particularly in the meiotic phase of germ cell development. Knockout studies in male mice have shown that loss of BEND2 disrupts the transition from zygonema to pachynema, interferes with chromosomal synapsis, and impairs the repair of DNA double-strand breaks, ultimately causing infertility. Additionally, BEND2's interaction with chromatin-associated proteins suggests its role in the formation of transcription-repressor complexes, essential for proper gene expression regulation during meiosis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BEN domain-containing protein 2
基因别名: BEND2; CXorf20
UniProt ID: (Human) Q8NDZ0
Entrez Gene ID: (Human) 139105
